Studies in the past two decades indicate that people often understand and remember text on paper better than on a screen. Screens may inhibit comprehension by preventing people from intuitively navigating and mentally mapping long texts. … In general, screens are also more cognitively and physically taxing than paper. Scrolling demands constant conscious effort, and LCD screens on tablets and laptops can strain the eyes and cause headaches by shining light directly on people 's faces. … Preliminary research suggests that even so-called digital natives are more likely to recall the gist of a story when they read it on paper because enhanced e-books and e-readers themselves are too distracting. Paper's greatest strength may be its simplicity.

In some ways, everything had changed, for Schadt now had four hundred people working for him, along with nine gene sequencers at his disposal and a supercomputer named Minerva in the basement. In other ways, however, he remained a guy in shorts, a guy whose face was always agleam in the light of his laptop, a guy whose office walls were decorated with a palimpsest of indecipherable equations. Most important, he remained a guy who never said no—who never rejected anything as impossible—and when he learned that a woman from Mississippi whom Esquire had written about eight years earlier had been told she had terminal colon cancer, Schadt looked up and said: "That's exactly the kind of patient we take." … It was, in the end, the reason he had come to New York. He probably didn't really need nine gene sequencers. He probably didn't even really need Minerva, because he could do supercomputing with Google and Amazon. But as both a lapsed molecular biologist and a lapsed Christian looking to establish a new faith, he needed something he had never had before. He needed patients. He needed someone like Stephanie Lee.

Inside a lab in Pisa, forensics pathologist Gino Fornaciari and his team investigate 500-year-old cold cases … Gino Fornaciari is no ordinary medical examiner; his bodies represent cold cases that are centuries, sometimes millennia, old. As head of a team of archaeologists, physical anthropologists, historians of medicine and additional specialists at the University of Pisa, he is a pioneer in the burgeoning field of paleopathology, the use of state-of-the-art medical technology and forensic techniques to investigate the lives and deaths of illustrious figures of the past. … Its practitioners worldwide are making startling discoveries.

Our research shows that the emerging economies’ share of Fortune Global 500 companies will probably jump to more than 45 percent by 2025, up from just 5 percent in 2000. That’s because while three-quarters of the world’s 8,000 companies with annual revenue of $1 billion or more are today based in developed economies, we forecast that an additional 7,000 could reach that size in little more than a decade—and 70 percent of them will most likely come from emerging markets. To put this dramatic shift in the balance of global corporate power in perspective, remember that many of the world’s largest companies have maintained their current status for generations: more than 40 percent of the 150 Western European companies in last year’s Fortune Global 500 had been founded before 1900. … The rebalancing of the global business landscape will probably be even faster and more dramatic than the shift of economic growth to emerging regions. Large companies matter, and not just for their ability to create jobs and generate higher incomes; they are also forces for increased productivity, innovation, standard setting, and the dissemination of skills and technology. Their geographic shift will have profound implications for the nature of competition, including not only the race for resources and talent but also, more broadly, the emerging markets’ efforts to reach the next level of economic development and prosperity.

It may be tempting to view recent declines in commodity prices as the end of the resource “supercycle”—the period of sharp price rises and heightened volatility since the turn of the 21st century. Yet rumors of the supercycle’s death are greatly exaggerated. Despite recent falls, commodity prices are still near their levels of early to mid-2008, just before the global financial crisis hit. (To track the movements in commodity prices over time, see the interactive, “MGI’s Commodity Price Index—an interactive tool.”) At a time when the world economy remains below full power, this phenomenon is striking, and a sign that the supercycle is alive and well. … We believe that resource markets will be shaped in coming years by a race between emerging-market demand and the resulting need to increase supply from a more challenging geology and the twin forces of supply-side innovation and resource productivity. Innovations such as the use of 3-D and 4-D seismic technologies for energy exploration can improve access to resources. Productivity gains can reduce the wastage of food and water and make buildings more energy efficient. The question is whether technology and resource productivity can improve fast enough to counter the impact of emerging-market demand and a more challenging geology. … The race is on.
1. The changing resource landscape
2. Energy: The race between technology and geology
3. Metals: The looming supply challenge
4. Agriculture: Falling yield growth hits prices

A flawed system for judging research is leading to academic fraud … As China tries to take its seat at the top table of global academia, the criminal underworld has seized on a feature in its research system: the fact that research grants and promotions are awarded on the basis of the number of articles published, not on the quality of the original research. This has fostered an industry of plagiarism, invented research and fake journals that Wuhan University estimated in 2009 was worth $150m, a fivefold increase on just two years earlier. … Chinese scientists are still rewarded for doing good research, and the number of high-quality researchers is increasing. Scientists all round the world also commit fraud. But the Chinese evaluation system is particularly susceptible to it.

The global obesity epidemic and related nutritional issues are arguably this century’s primary social health concern. With breakthroughs in the field of medicine, huge leaps in cancer research and diseases such as smallpox and polio largely eradicated, people around the globe are, on average, living much longer and healthier than they were decades ago. The focus on well-being has shifted from disease to diet. The whole concept of healthy living is a key pillar of our Credit Suisse Mega - trends framework – themes we consider crucial in the evolution of the investment world. In this report, we specifically explore the impact of “sugar and sweeteners” on our diets. ... Although medical research is yet to prove conclusively that sugar is in fact the leading cause of obesity, diabetes type II or metabolic syndrome, we compare and contrast various studies on its metabolic effects and nutritional impact. Alongside this, we question some of the accepted wisdom as to what is perceived as “good” and “bad” when it comes to sugar consumption, namely as to whether a calorie consumed is the same regardless of where it is derived from – sugar, fats, or protein – and whether solid foods are “nutritionally different” to liquids. ... What can we expect in the future? What should investors focus on? Although a major consumer shift away from sugar and high-fructose corn syrup may be some years away, and outright taxation and regulation a delicate process, there is now a trend developing. From the expansion of “high-intensity” natural sweeteners to an increase in social responsibility mes - sages from the beverage manufacturers, we see green shoots for dietary changes and social health advancement. Ultimately, we expect consumers, doctors, manufacturers and legislators to all play a crucial role in changing the status quo for sugar.

Our central finding is that the hype may actually understate the full potential—but that capturing it will require an understanding of where real value can be created and a successful effort to address a set of systems issues, including interoperability. ... To get a broader view of the IoT’s potential benefits and challenges across the global economy, we analyzed more than 150 use cases, ranging from people whose devices monitor health and wellness to manufacturers that utilize sensors to optimize the maintenance of equipment and protect the safety of workers. Our bottom-up analysis for the applications we size estimates that the IoT has a total potential economic impact of $3.9 trillion to $11.1 trillion a year by 2025. At the top end, that level of value—including the consumer surplus—would be equivalent to about 11 percent of the world economy ... Achieving this kind of impact would require certain conditions to be in place, notably overcoming the technical, organizational, and regulatory hurdles. In particular, companies that use IoT technology will play a critical role in developing the right systems and processes to maximize its value. ... The digitization of machines, vehicles, and other elements of the physical world is a powerful idea. Even at this early stage, the IoT is starting to have a real impact by changing how goods are made and distributed, how products are serviced and refined, and how doctors and patients manage health and wellness. But capturing the full potential of IoT applications will require innovation in technologies and business models, as well as investment in new capabilities and talent. With policy actions to encourage interoperability, ensure security, and protect privacy and property rights, the Internet of Things can begin to reach its full potential—especially if leaders truly embrace data-driven decision making.

Seventy years after the destruction of Hiroshima and Nagasaki by nuclear weapons, David Kaiser investigates the legacy of 'the physicists' war'. ... The Second World War marked an unprecedented mobilization of scientists and engineers, and a turning point in the relationship between research and the state. By the end of the war, the nuclear weapons project, code-named the Manhattan Engineer District, absorbed thousands of researchers and billions of dollars. It sprawled across 30 facilities throughout the United States and Canada, with British teams working alongside Americans and Canadians. Allied efforts on radar swelled to comparable scale. ... the term had been coined long before August 1945, and originally it had nothing to do with bombs or radar. Rather, the physicists' war had referred to an urgent, ambitious training mission: to teach elementary physics to as many enlisted men as possible. ... Both views of how scientists could serve their nations — the quotidian and the cataclysmic — have shaped scientific research and higher education to this day.

The world is about to experience an unprecedented consumption boom, which presents both challenges and opportunities for investors everywhere. Animal protein consumption, energy, air travel, health care, and education are some of the most relevant sectors involved as the upcoming changes in population and income collide. ... The world in general—and India in particular— is in the midst of a fascinating transition right now. Taking a step back from our day-to-day focus to view the bigger picture can offer a different perspective on the dynamics of various countries in a volatile and uncertain world. Envision a map that is drawn to represent how economists view the world. Imagine a map on which the area occupied by a country as a percentage of total area is equivalent to its percentage of global GDP. Compared with traditional maps, in which country sizes are based on land area, the United States, Europe, and definitely Japan would appear bloated. Other regions would look smaller—for example, Africa or India. Africa especially is quite difficult to see on the economists’ map. ... Now, imagine another map on which land area is proportionate to the country’s percentage of the global population. If the United States is viewed this way, it will be much smaller than on the economists’ map. In the population map, Africa would become relevant and uncertainties about the importance of India and China would disappear. Focusing on the differences in these maps may permit us to realize our biases in viewing the world.

Diseases spread by ticks are on the rise around the world, spurred by a combination of factors, including shifting climates and population sprawl into rural areas. Reported cases of Lyme, the most common US tick-borne illness, have nearly tripled in the country since 1992, although some of the increase could be due to heightened awareness. Lyme is also a growing problem in parts of Europe, Mongolia and China. Yet as bad as it is, there are nastier threats on the rise. In parts of Africa, the Middle East, Asia and southern Europe, ticks can spread Crimean–Congo haemorrhagic fever, which is fatal in 40% of cases. And a tick-borne relapsing fever afflicts as many as 1 in 20 residents in parts of Senegal. In the United States, ticks spread at least 16 illnesses, including anaplasmosis, babesiosis, ehrlichiosis and Rocky Mountain spotted fever, all “serious, life-threatening infections”, Beard says. And many are increasing in incidence more quickly than Lyme. In a July 2015 position statement, the Entomological Society of America argued for a national strategy to combat tick-borne diseases. “The recent confluence of environmental, ecological, sociological, and human demographic factors,” it said, “has created a near 'perfect storm' leading to more ticks in more places throughout North America.”

But the real problem was the large number of Byzantine shipwrecks that began to surface soon after the excavation began, in 2004. Dating from the fifth to the eleventh century, the shipwrecks illustrated a previously murky chapter in the history of shipbuilding and were exceptionally well preserved, having apparently been buried in sand during a series of natural disasters. ... From 2005 to 2013, workers with shovels and wheelbarrows extracted a total of thirty-seven shipwrecks. When the excavation reached what had been the bottom of the sea, the archeologists announced that they could finally cede part of the site to the engineers, after one last survey of the seabed—just a formality, really, to make sure they hadn’t missed anything. That’s when they found the remains of a Neolithic dwelling, dating from around 6000 B.C. It was previously unknown that anyone had lived on the site of the old city before around 1300 B.C. The excavators, attempting to avoid traces of Istanbul’s human history, had ended up finding an extra five thousand years of it. It took five years to excavate the Neolithic layer, which yielded up graves, huts, cultivated farmland, wooden tools, and some two thousand human footprints, miraculously preserved in a layer of silt-covered mud. In the Stone Age, the water level of the Bosporus was far lower than it is now; there’s a chance that the people who left those prints might have been able to walk from Anatolia to Europe. ... In 2013, at least two million people crossed the Bosporus daily, by bridge or ferry; the number of motor-vehicle crossings rose eleven hundred and eighty per cent between 1988 and 2012. ... Wood can absorb eight times its mass in water. If allowed to dry naturally, it cracks and warps beyond recognition.

From 1980 to 2013, vast markets opened around the world while corporate-tax rates, borrowing costs, and the price of labor, equipment, and technology all fell. The net profits posted by the world’s largest companies more than tripled in real terms from $2 trillion in 1980 to $7.2 trillion by 2013,1 pushing corporate profits as a share of global GDP from 7.6 percent to almost 10 percent. Today, companies from advanced economies still earn more than two-thirds of global profits, and Western firms are the world’s most profitable. Multinationals have benefited from rising consumption and industrial investment, the availability of low-cost labor, and more globalized supply chains. ... But there are indications of a very significant change in the nature of global competition and the economic environment. While global revenue could increase by some 40 percent, reaching $185 trillion by 2025, profit growth is coming under pressure. This could cause the real-growth rate for the corporate-profit pool to fall from around 5 percent to 1 percent, practically the same share as in 1980, before the boom began. ... Profits are shifting from heavy industry to idea-intensive sectors that revolve around R&D, brands, software, and algorithms. Sectors such as finance, information technology, media, and pharmaceuticals—which have the highest margins—are developing a winner-take-all dynamic, with a wide gap between the most profitable companies and everyone else. Meanwhile, margins are being squeezed in capital-intensive industries, where operational efficiency has become critical. ... As profit growth slows, there will be more companies fighting for a smaller slice of the pie, and incumbent industry leaders cannot focus simply on defending their market niche.

Everyone at the Napa meeting had access to a gene-editing technique called Crispr-Cas9. The first term is an acronym for “clustered regularly interspaced short palindromic repeats,” a description of the genetic basis of the method; Cas9 is the name of a protein that makes it work. Technical details aside, Crispr-Cas9 makes it easy, cheap, and fast to move genes around—any genes, in any living thing, from bacteria to people. ... Using the three-year-old technique, researchers have already reversed mutations that cause blindness, stopped cancer cells from multiplying, and made cells impervious to the virus that causes AIDS. Agronomists have rendered wheat invulnerable to killer fungi like powdery mildew, hinting at engineered staple crops that can feed a population of 9 billion on an ever-warmer planet. Bioengineers have used Crispr to alter the DNA of yeast so that it consumes plant matter and excretes ethanol, promising an end to reliance on petrochemicals. Startups devoted to Crispr have launched. International pharmaceutical and agricultural companies have spun up Crispr R&D. Two of the most powerful universities in the US are engaged in a vicious war over the basic patent. Depending on what kind of person you are, Crispr makes you see a gleaming world of the future, a Nobel medallion, or dollar signs. ... It brings with it all-new rules for the practice of research in the life sciences. But no one knows what the rules are—or who will be the first to break them. ... As it happened, the people who found it weren't genome engineers at all. They were basic researchers, trying to unravel the origin of life by sequencing the genomes of ancient bacteria and microbes called Archaea (as in archaic), descendants of the first life on Earth. Deep amid the bases, the As, Ts, Gs, and Cs that made up those DNA sequences, microbiologists noticed recurring segments that were the same back to front and front to back—palindromes. The researchers didn't know what these segments did, but they knew they were weird. In a branding exercise only scientists could love, they named these clusters of repeating palindromes Crispr. ... Pick your creature, pick your gene, and you can bet someone somewhere is giving it a go.

I’d like to tell the story of a paradox: How do we bring the right people to the right place at the right time to discover something new, when we don’t know who or where or when that is, let alone what it is we’re looking for? This is the paradox of innovation: If so many discoveries — from penicillin to plastics – are the product of serendipity, why do we insist breakthroughs can somehow be planned? Why not embrace serendipity instead? Because here’s an example of what happens when you don’t. ... By one estimate, the rate of new drugs developed per dollar spent by the industry has fallen by roughly a factor of 100 over the last 60 years. Patent statistics tell a similar story across industry after industry, from chemistry to metalworking to clean energy, in which top-down innovation has only grown more expensive and less efficient over time. ... Instead of speeding up the pace of discovery, large hierarchical organizations are slowing down — a stagflationary principle known as “Eroom’s Law,” which is “Moore’s Law” spelled backwards. ... Any society that values novelty and new ideas (like our innovation-obsessed one) will invariably trend toward greater serendipity over time. The push toward greater diversity, better public spaces, and an expanded public sphere all increase the potential for fortuitous discoveries.

The events of 2015 have shown that China is passing through a challenging transition: the labor-force expansion and surging investment that propelled three decades of growth are now weakening. This is a natural stage in the country’s economic development. Yet it raises questions such as how drastically the expansion of GDP will slow down and whether the country can tap new sources of growth. ... to realize consensus growth forecasts—5.5 to 6.5 percent a year—during the coming decade, China must generate two to three percentage points of annual GDP growth through innovation, broadly defined. If it does, innovation could contribute much of the $3 trillion to $5 trillion a year to GDP by 2025. China will have evolved from an “innovation sponge,” absorbing and adapting existing technology and knowledge from around the world, into a global innovation leader. Our analysis suggests that this transformation is possible, though far from inevitable. ... To develop a clearer view of this potential, we identified four innovation archetypes: customer focused, efficiency driven, engineering based, and science based. We then compared the actual global revenues of individual industries with what we would expect them to generate given China’s share of global GDP (12 percent in 2013). As the exhibit shows, Chinese companies that rely on customer-focused and efficiency-driven innovation—in industries such as household appliances, Internet software and services, solar panels, and construction machinery—perform relatively well.
1. Customer-focused innovation: The Chinese commercialization machine
2. Efficiency-driven innovation: The ecosystem advantage
3. Engineering-based innovation in ‘learning industries’
4. Science-based innovation: Novel Chinese approaches

How a 500-year experiment to revive dormant microbes could reveal the secrets to cheating time ... For almost as long as we have known about micro-organisms, we have known about dormancy. In 1702, the Dutch biologist Antonie van Leeuwenhoek collected some dried ‘animalcules’ from a nearby gutter and added water. Peering through his handmade microscope, he observed that ‘they began to extend their bodies and in half an hour at least 100 of them were swimming about the glass’. ... Aged 70, van Leeuwenhoek had just discovered the dormant states of rotifers – small, wheel-shaped animals that can be found in many transient freshwater habitats. When conditions become too Spartan, these humble organisms contract into dry, oval-shaped husks in order to survive. ... Water is essential for life, and yet anhydrobiotes appear to get by without it. How? According to the ‘water replacement hypothesis’, they exchange their cellular fluid for sugars such as sucrose and trehalose. The result is a glass-like substance that not only retains the cell’s shape on rehydration, but also slows down a lot of unwanted chemical reactions. With this scaffolding in place, they reduce the fires of their metabolisms to embers, conserving their energy like a ground squirrel within its winter den, waiting for conditions to improve. They keep things ticking over.

Meet the iChip, a plastic block that helped scientists discover a new antibiotic that kills superbugs. Will it be enough to save humankind from the coming bacterial apocalypse? ... Even more exciting is the innovation used to discover teixobactin: the unassuming plastic blocks. Each one is called an iChip, short for isolation chip, so-named because of how it captures microbes from soil. Until now, scientists hunting for antibiotics haven’t been able to study 99 percent of the world’s microbial species because, when ripped from the outdoors and encouraged to grow under desolate laboratory conditions, the vast majority of bacteria die. The iChip overcomes this problem by keeping things dirty: Burying soil microbes in their natural habitat during the culturing process preserves the organic compounds they need to thrive, enticing previously stubborn microorganisms to multiply under human supervision. ... An investigation by a U.K. government task force estimates that the global toll of antibiotic resistance is 700,000 deaths per year—and that it could soar to 10 million by 2050. In the United States, at least 2 million people are infected with antibiotic-immune bacteria annually; some 23,000 die. (The director of the Centers for Disease Control and Prevention has called the estimate “a bare minimum.”) All that illness and death exacts substantial economic losses, too: The U.K. task force projects that resistance will sap between 2 and 3.5 percent of the world’s GDP—about $100 trillion—over the next 35 years. ... The iChip could prove an essential tool for warding off bacteria’s looming assault on humans, but it’s not a cure-all. ... Rather than trying to determine what biological compounds soil bacteria need to flourish—science still doesn’t have a precise answer—he focused on the simple fact that many microbes are happy in dirt.

Science is not a ‘body of knowledge’ – it’s a dynamic, ongoing reconfiguration of knowledge and must be free to change ... each scientific discipline is governed by an accepted set of theories and metaphysical assumptions, within which normal science operates. Periodically, when this rather humdrum ‘puzzle solving’ leads to results that are inconsistent with the regnant perspective, there follows a disruptive, exciting period of ‘scientific revolution’, after which a new paradigm is instituted and normal science can operate once more. ... When Newton said: ‘If I have seen farther, it is by standing on the shoulders of giants’, he wasn’t merely being modest; rather he was emphasising the extent to which science is cumulative, mostly building on past achievements rather than making quantum leaps. ... the accumulation process generates not just something more, but often something altogether new. Sometimes the new involves the literal discovery of something which hadn’t previously been known (electrons, general relativity, Homo naledi). At least as important, however, are conceptual novelties, changes in the ways that people understand – and often misunderstand – the material world: their operating paradigms. ... The world’s factual details are in continual Heraclitean flux, but the basic rules and patterns underlying these changes in the physical and biological world are themselves constant. ... Our insights, however, are always ‘evolving’. ... Science is a process, which, unlike ideology, is distinguished by intellectual flexibility, by a graceful, grateful (albeit sometimes grudging) acceptance of the need to change our minds, as our understanding of the world evolves. Most people aren’t revolutionaries, scientific or otherwise. But anyone aspiring to be well-informed needs to understand not only the most important scientific findings, but also their provisional nature, and the need to avoid hardening of the categories: to know when it is time to lose an existing paradigm and replace it with a new one. ... Holding still is exactly what science won’t do.

In the 1980s, two ecologists, Jim Brown at the University of New Mexico and Brian Maurer at Brigham Young University, coined the term macroecology, which gave a name and intellectual home to researchers searching for emergent patterns in nature. Frustrated by the small scale of many ecological studies, macroecologists were looking for patterns and theories that could allow them to describe nature broadly in time and space. ... Brown and Maurer had been influenced heavily by regularities in many ecological phenomena. One of these, called the species-area curve, was discovered back in the 19th century, and formalized in 1921. That curve emerged when naturalists counted the number of species (of plants, insects, mammals, and so on) found in plots laid out in backyards, savannahs, and forests. They discovered that the number of species increased with the area of the plot, as expected. But as the plot size kept increasing, the rate of increase in the number of species began to plateau. Even more remarkable, the same basic species-area curve was found regardless of the species or habitat. To put it mathematically, the curve followed a power law, in which the change in species number increased proportionally to the square root of the square root of the area. ... Power laws are common in science, and are the defining feature of universality in physics. They describe the strength of magnets as temperature increases, earthquake frequency versus size, and city productivity as a function of population.

The internet promised to feed our minds with knowledge. What have we learned? That our minds need more than that ... My point is not that we should return to some romanticised preindustrial past: I mean only to draw attention to contradictions that still shape our post-industrial present. The physical violence of the 19th-century factory might be gone, at least in the countries where industrialisation began, but the alienation inherent in these ways of organising work remains. ... When the internet arrived, it seemed to promise a liberation from the boredom of industrial society, a psychedelic jet-spray of information into every otherwise tedious corner of our lives. In fact, at its best, it is something else: a remarkable helper in the search for meaningful connections. But if the deep roots of boredom are in a lack of meaning, rather than a shortage of stimuli, and if there is a subtle, multilayered process by which information can give rise to meaning, then the constant flow of information to which we are becoming habituated cannot deliver on such a promise. At best, it allows us to distract ourselves with the potentially endless deferral of clicking from one link to another. Yet sooner or later we wash up downstream in some far corner of the web, wondering where the time went. The experience of being carried on these currents is quite different to the patient, unpredictable process that leads towards meaning.

This apple had been carefully grown somewhere in Washington state, the result of millions of dollars and two decades of labor. Break apart its unremarkable surface to reveal its flesh, wait long enough, and you’ll see what’s different: It remains pure white. It doesn’t start to brown right after you take a bite and leave it on the kitchen counter. In fact, it doesn’t start to brown until it molds or rots. It doesn’t bruise, either. Through a feat of genetic engineering, Carter’s apples hold on indefinitely to the pearly-white insides that inspired their name — the Arctic. ... The Arctic was conceived by Carter’s company, Okanagan Specialty Fruits, which he runs with his wife, Louisa, and four other full-time employees, newly under the umbrella of a large biotech company that bought it this year. It’s an intended solution to what Carter sees as two interrelated problems: First, millions of pounds of perfectly good apples get dumped every year because they look a little too bruised or brown, the victims of an instinctive human aversion to fruits and vegetables that aren’t smooth, shiny, and symmetrical. And at the same time, North American consumers, accustomed to 100-calorie packs and grab-and-go everything, have developed an impatience for food that can’t be quickly eaten. ... Taken together, these two trends mean that while apple consumption has flatlined in the United States for decades, a staggering amount of apples go wasted. ... Apples in particular have been transformed dramatically by commercial cultivation and serendipitous acts of nature over the last two millennia. The apples grocery store shoppers pluck off shelves in 2015 are vastly different from the ones first discovered in Kazakhstan, or even the ones grown by Johnny Appleseed in the 19th century. ... A study in the Journal of Consumer Affairs estimated that $15 billion in fresh and processed fruit was lost from the U.S. food supply in 2008 — about $9 billion at the consumer level and the rest at the retail level.

Burgers and fries have nearly killed our ancestral microbiome. ... A group of Italian microbiologists had compared the intestinal microbes of young villagers in Burkina Faso with those of children in Florence, Italy. The villagers, who subsisted on a diet of mostly millet and sorghum, harbored far more microbial diversity than the Florentines, who ate a variant of the refined, Western diet. Where the Florentine microbial community was adapted to protein, fats, and simple sugars, the Burkina Faso microbiome was oriented toward degrading the complex plant carbohydrates we call fiber. ... Scientists suspect our intestinal community of microbes, the human microbiota, calibrates our immune and metabolic function, and that its corruption or depletion can increase the risk of chronic diseases, ranging from asthma to obesity. ... Numerous factors are implicated in these disappearances. Antibiotics, available after World War II, can work like napalm, indiscriminately flattening our internal ecosystems. Modern sanitary amenities, which began in the late 19th century, may limit sharing of disease- and health-promoting microbes alike. Today’s houses in today’s cities seal us away from many of the soil, plant, and animal microbes that rained down on us during our evolution, possibly limiting an important source of novelty. ... But what the Sonnenburgs’ experiment suggests is that by failing to adequately nourish key microbes, the Western diet may also be starving them out of existence.

Elizabeth Holmes rarely slips out of character. When she responds to questions in an interview or on a conference stage, she leans forward, leg crossed ankle over knee in a half-lotus manspread power pose. She lowers her voice an octave or two, as if she’s plumbing the depths of the human vocal cord. Although she hates it being remarked upon, her clothing, a disciplined all-black ensemble of flat shoes, slacks, turtleneck, and blazer buttoned at the waist, is impossible not to notice. She adopted this uniform, as she calls it, in 2003, when she founded Theranos, a company seeking to revolutionize the medical diagnostics industry by doing tests using only a few drops of blood. ... “I wanted the focus to be on my work,” she says slowly and deliberately. “I don’t want to go into a meeting and have people looking at what I’m wearing. I want them listening to what I’m saying. And I want them to be looking at what we do.” ... She was only too willing to let that propel her through the business media’s star chamber, though she refused to let photographers use a wind machine to blow her hair. ... After several years of Holmes telling the largely unchallenged story of how Theranos intends to change the world, a blast of cold air came ... Most blood work in the U.S. is run on analyzer machines made by companies such as Siemens, Roche Diagnostics, and Olympus. The labs that buy these machines don’t need the FDA’s OK to use them, but the manufacturers need it to sell them. ... FDA clearance alone may not be enough to convince physicians that the tests can be used for all patients, according to John Ioannidis, a professor of medicine at Stanford who’s best known for his criticism of the way scientific research is conducted, in particular for a 2005 paper titled “Why Most Published Research Findings Are False.”

He says it’s a self-driving car that he had built in about a month. The claim seems absurd. But when I turn up that morning, in his garage there’s a white 2016 Acura ILX outfitted with a laser-based radar (lidar) system on the roof and a camera mounted near the rearview mirror. A tangle of electronics is attached to a wooden board where the glove compartment used to be, a joystick protrudes where you’d usually find a gearshift, and a 21.5-inch screen is attached to the center of the dash. “Tesla only has a 17-inch screen,” Hotz says. ... Hotz was the first person to hack Apple’s iPhone, allowing anyone—well, anyone with a soldering iron and some software smarts—to use the phone on networks other than AT&T’s. He later became the first person to run through a gantlet of hard-core defense systems in the Sony PlayStation 3 and crack that open, too. ... The technology he’s building represents an end run on much more expensive systems being designed by Google, Uber, the major automakers, and, if persistent rumors and numerous news reports are true, Apple. More short term, he thinks he can challenge Mobileye, the Israeli company that supplies Tesla Motors, BMW, Ford Motor, General Motors, and others with their current driver-assist technology. ... Hotz plans to best the Mobileye technology with off-the-shelf electronics. He’s building a kit consisting of six cameras—similar to the $13 ones found in smartphones—that would be placed around the car. ... The goal is to sell the camera and software package for $1,000 a pop either to automakers or, if need be, directly to consumers who would buy customized vehicles at a showroom run by Hotz. ... There are two breakthroughs that make Hotz’s system possible. The first comes from the rise in computing power since the days of the Grand Challenge. He uses graphics chips that normally power video game consoles to process images pulled in by the car’s camera and speedy Intel chips to run his AI calculations. ... The second advance is deep learning, an AI technology that has taken off over the past few years. It allows researchers to assign a task to computers and then sit back as the machines in essence teach themselves how to accomplish and finally master the job. ... Instead of the hundreds of thousands of lines of code found in other self-driving vehicles, Hotz’s software is based on about 2,000 lines.