The epic begins 10,000 years ago in an Asian jungle and ends today in kitchens all over the world ... The chickens that saved Western civilization were discovered, according to legend, by the side of a road in Greece in the first decade of the fifth century B.C. The Athenian general Themistocles, on his way to confront the invading Persian forces, stopped to watch two cocks fighting and summoned his troops, saying: “Behold, these do not fight for their household gods, for the monuments of their ancestors, for glory, for liberty or the safety of their children, but only because one will not give way to the other.” The tale does not describe what happened to the loser, nor explain why the soldiers found this display of instinctive aggression inspirational rather than pointless and depressing. But history records that the Greeks, thus heartened, went on to repel the invaders, preserving the civilization that today honors those same creatures by breading, frying and dipping them into one’s choice of sauce. The descendants of those roosters might well think—if they were capable of such profound thought—that their ancient forebears have a lot to answer for.
A. gambiae has been called the world’s most dangerous animal, although strictly speaking that applies only to the female of the species, which does the bloodsucking and harms only indirectly. Its bite is a minor nuisance, unless it happens to convey the malaria parasite, Plasmodium falciparum, for which it is a primary human vector. Although a huge international effort has cut malaria mortality by about half since 2000, the World Health Organization still estimates there were more than 400,000 fatal cases in 2015, primarily in Africa. Children are particularly susceptible. The Bill and Melinda Gates Foundation prioritized malaria in its more than $500 million commitment to fight infectious disease in developing countries. ... Humans have been at war with members of the family Culicidae for over a century, since the pioneering epidemiologist Sir Ronald Ross proved the role of Anopheles in malaria and U.S. Army Maj. Walter Reed made a similar discovery about Aedes aegypti and yellow fever. The war has been waged with shovels and insecticides, with mosquito repellent, mosquito traps and mosquito-larvae-eating fish, with bed nets and window screens and rolled-up newspapers. But all of these approaches are self-limiting. Puddles fill up again with rain; insects evolve resistance to pesticides; predators can eat only so much. ... If Crisanti’s approach works, you could, in theory, wipe out an entire species of mosquito. You could wipe out every species of mosquito, although you’d need to do them one at a time, and there are around 3,500 of them, of which only about 100 spread human disease. You might want to stop at fewer than a dozen species in three genera—Anopheles (translation: “useless,” the malaria mosquito), Aedes (translation: “unpleasant,” the principal vector for yellow fever, dengue and Zika) and Culex (translation: “gnat,” responsible for spreading West Nile, St. Louis encephalitis and other viruses).