Perhaps the greatest polo player ever, Adolfo Cambiaso is planning to compete on a pony that died nearly a decade ago—a clone of his beloved stallion Aiken Cura. With more than 25 replicas of champion horses now in existence, Haley Cohen explores how the science came to polo. ... Aiken Cura is one of a number of horses that Cambiaso has duplicated. Through their company, Crestview Genetics, Cambiaso and two wealthy polo enthusiasts—the founder, Texan Alan Meeker, and Argentinean tycoon Ernesto Gutiérrez—have created more than 25 clones of Cambiaso’s champion polo horses and around 45 clones in total. Some are already breeding, and a few others began to play in top tournaments last year. Since the company’s establishment, in 2009, the partners have cloned not only for themselves but also for other international polo players who are willing to shell out around $120,000 per horse. Crestview is one of only two commercial groups in the world replicating polo horses, and it is the more prolific. ... Cloning began long before the world started paying attention to it, in 1996, when Dolly the Sheep, the first mammal successfully cloned from an adult cell, clomped into the world. One hundred years before, in 1885, Hans Driesch created two identical sea urchins by jiggling a two-celled urchin embryo until the cells separated and grew into their own creatures. Through much more sophisticated processes, scientists have since cloned pigs, cows, dogs, cats, ferrets, goats, and horses. (It is estimated that there are now around 300 cloned horses in the world, although no one has really kept track.) Now, with Crestview’s efforts, polo—the ancient “game of kings”—has found itself on the frontiers of cloning technology. ... “I did the math and realized it would take me $100 million and 50 years to get the quality of horses I wanted through conventional breeding,” he says. “I decided I didn’t want to spend either.” Instead, he turned to cloning.

Everyone at the Napa meeting had access to a gene-editing technique called Crispr-Cas9. The first term is an acronym for “clustered regularly interspaced short palindromic repeats,” a description of the genetic basis of the method; Cas9 is the name of a protein that makes it work. Technical details aside, Crispr-Cas9 makes it easy, cheap, and fast to move genes around—any genes, in any living thing, from bacteria to people. ... Using the three-year-old technique, researchers have already reversed mutations that cause blindness, stopped cancer cells from multiplying, and made cells impervious to the virus that causes AIDS. Agronomists have rendered wheat invulnerable to killer fungi like powdery mildew, hinting at engineered staple crops that can feed a population of 9 billion on an ever-warmer planet. Bioengineers have used Crispr to alter the DNA of yeast so that it consumes plant matter and excretes ethanol, promising an end to reliance on petrochemicals. Startups devoted to Crispr have launched. International pharmaceutical and agricultural companies have spun up Crispr R&D. Two of the most powerful universities in the US are engaged in a vicious war over the basic patent. Depending on what kind of person you are, Crispr makes you see a gleaming world of the future, a Nobel medallion, or dollar signs. ... It brings with it all-new rules for the practice of research in the life sciences. But no one knows what the rules are—or who will be the first to break them. ... As it happened, the people who found it weren't genome engineers at all. They were basic researchers, trying to unravel the origin of life by sequencing the genomes of ancient bacteria and microbes called Archaea (as in archaic), descendants of the first life on Earth. Deep amid the bases, the As, Ts, Gs, and Cs that made up those DNA sequences, microbiologists noticed recurring segments that were the same back to front and front to back—palindromes. The researchers didn't know what these segments did, but they knew they were weird. In a branding exercise only scientists could love, they named these clusters of repeating palindromes Crispr. ... Pick your creature, pick your gene, and you can bet someone somewhere is giving it a go.

Human genomics is just the beginning: the Earth has 50 billion tons of DNA. What happens when we have the entire biocode? ... By 2020, many hospitals will have genomic medicine departments, designing medical therapies based on your personal genetic constitution. Gene sequencers – machines that can take a blood sample and reel off your entire genetic blueprint – will shrink below the size of USB drives. Supermarkets will have shelves of home DNA tests, perhaps nestled between the cosmetics and medicines, for everything from whether your baby will be good at sports to the breed of cat you just adopted, to whether your kitchen counter harbours enough ‘good bacteria’. We will all know someone who has had their genome probed for medical reasons, perhaps even ourselves. Personal DNA stories – including the quality of the bugs in your gut– will be the stuff of cocktail party chitchat. ... Due to satellite imaging, we can see the entire surface of our planet. There can be no undiscovered land masses. The map of the world is complete. And we should expect the same thing for genetics. DNA testing will become so pervasive it will transform the medical, legal and social foundations of society. If blanket genome sequencing takes off, it will be impossible to obscure human relationships or ignore the content of our DNA. ... One of the greatest achievements of the coming century will be the characterisation of the Biocode, not just as a list of genomes of different species, but as patterns of interacting communities. ... By 2050 we should aim to finally have a handle not only on human genetic diversity but on the biodiversity of the planet.

To help feed billions of people, scientists braved the snake-infested and croc-filled swamps of northern Australia in search of rice. ... Musgrave is one of a few pit stops along the rutted, mostly dirt road that traverses Cape York, Australia, and ends at the northeasternmost tip of the continent, just 100 miles from Papua New Guinea. The peninsula is part of the world’s greatest concentration of free-flowing rivers and its most extensive network of intact tropical savannas, which stretches across the country’s north for hundreds of miles. Even in a country where open spaces rule the landscape, this place looms in the national mind as an uncharted, prehistoric mystery. This year alone, scientists discovered 13 new spider species on the peninsula. Cape York is roughly the size of Nebraska but with only 17,000 residents, most of whom are indigenous and clustered in a few towns along the coast. ... Grown on six continents and in 117 countries, rice is the world’s most important food. There are 144 million farms that grow rice, more than for any other crop. The vast majority of these are in developing countries, and virtually all of them are small, averaging just over 2 acres apiece. Simply put, the crop is the daily sustenance of the world’s poor. The primary reason is its remarkable biology. Rice is naturally prolific, each plant generating perhaps 25 times as many grains as a single wheat plant. When grown in water, its microbiome regenerates the soil’s nutrition, making fertilizer unnecessary. ... In recent decades, an increasing number of geneticists and plant breeders have realized that crops’ wild relatives hold immense value because they have not been domesticated. Instead of being narrowed and homogenized by humans, these crops have produced immeasurable genetic diversity as a result of their natural adaptation to pests, diseases, and climatic fluctuation. Their genes have already begun to help agriculture tackle the enormous challenges it faces today.

Convinced that having a family might not be in the cards for him, Ed Houben (pronounced who-been) decided to become a sperm donor. He would show up twice a month at the clinic, “producing” in “the production room” to fill a cup for cash. The first time he went, they didn't even take his name. It couldn't have been more cold and impersonal. ... Ed Houben is now, at the age of 46, one of the preeminent makers of babies on the planet, father to 106 children of whom two-thirds were made the natural way (i.e., by sexual intercourse) and a third made via artificial insemination. In addition, there are 30 or so he estimates from his years at the clinic. Put another way: Ed Houben, who once had sex once every decade, has fathered roughly ten kids every year for the past 15 years. And he's still at it, thumping his way into history. So prodigious is his legacy that the BBC dubbed him “Europe's most virile man,” while he regularly gets billed by media as “the Sperminator.” ... he's quick to describe himself as a “truly ugly fat guy with glasses.” ... it's disorienting, for Ed lives in what might truly be considered a morally ambiguous space that he argues isn't ambiguous at all. “I really believe children should be conceived from an act of kindness and that they deserve to know their father as more than a number,” he says. “I forbid myself to feel proud of what I do. I don't have any children; other people have children because of a small contribution from me.”

Industrial production destroyed both the taste and the nutritional value of wheat. One scientist believes he can undo the damage. ... Commodity wheats are defined in just three ways: hard (high in protein, which is good for bread) or soft (better for pastries); red (dark color and strong flavor) or white (pale and more delicate-tasting); and winter or spring, depending on when they are planted. ‘‘Hard red spring,’’ for example, is often used for bread; ‘‘soft white winter’’ is better for pastries. A vast majority of America’s 56 million acres of wheat grow in a belt stretching more than 1,000 miles from the Canadian border to Central Texas. Around half of the crop is exported, and most of what remains is funneled to feedlots for cattle or to giant mills and bread factories, which churn out all those bags of generic white flour and limp sandwich bread sleeved twice in plastic. This industrial system forces plant breeders to prioritize wheat kernels of highly specific sizes, colors and hardness. ... What would happen, Jones wondered, if he developed unique varieties of wheat adapted to the Skagit’s cool, wet climate and extremely fertile soil? What if he could interest local millers and bakers in dealing primarily with Washington wheat? What if wheat, like wine, had terroir? After all, it used to. ... A grain of wheat has three main components: a fibrous and nutrient-rich outer coating called the bran; the flavorful and aromatic germ, a living embryo that eventually develops into the adult plant; and a pouch of starch known as the endosperm, which makes up the bulk of the grain. Before roller mills, all three parts were mashed together when processed. As a result, flour was not the inert white powder most of us are familiar with today ... Roller mills solved this problem. Their immense spinning cylinders denuded the endosperm and discarded the germ and bran, producing virtually unspoilable alabaster flour composed entirely of endosperm. It was a boon for the growing flour industry: Mills could now source wheat from all over, blend it to achieve consistency and transport it across the nation without worrying about shelf life. That newfound durability came at a huge cost, however, sacrificing much of the grain’s flavor and nutrition.

This apple had been carefully grown somewhere in Washington state, the result of millions of dollars and two decades of labor. Break apart its unremarkable surface to reveal its flesh, wait long enough, and you’ll see what’s different: It remains pure white. It doesn’t start to brown right after you take a bite and leave it on the kitchen counter. In fact, it doesn’t start to brown until it molds or rots. It doesn’t bruise, either. Through a feat of genetic engineering, Carter’s apples hold on indefinitely to the pearly-white insides that inspired their name — the Arctic. ... The Arctic was conceived by Carter’s company, Okanagan Specialty Fruits, which he runs with his wife, Louisa, and four other full-time employees, newly under the umbrella of a large biotech company that bought it this year. It’s an intended solution to what Carter sees as two interrelated problems: First, millions of pounds of perfectly good apples get dumped every year because they look a little too bruised or brown, the victims of an instinctive human aversion to fruits and vegetables that aren’t smooth, shiny, and symmetrical. And at the same time, North American consumers, accustomed to 100-calorie packs and grab-and-go everything, have developed an impatience for food that can’t be quickly eaten. ... Taken together, these two trends mean that while apple consumption has flatlined in the United States for decades, a staggering amount of apples go wasted. ... Apples in particular have been transformed dramatically by commercial cultivation and serendipitous acts of nature over the last two millennia. The apples grocery store shoppers pluck off shelves in 2015 are vastly different from the ones first discovered in Kazakhstan, or even the ones grown by Johnny Appleseed in the 19th century. ... A study in the Journal of Consumer Affairs estimated that $15 billion in fresh and processed fruit was lost from the U.S. food supply in 2008 — about $9 billion at the consumer level and the rest at the retail level.

Is every healthy child a potential prodigy? ... Before Laszlo Polgár conceived his children, before he even met his wife, he knew he was going to raise geniuses. He’d started to write a book about it. He saw it moves ahead. ... By their first meeting, a dinner and walk around Budapest in 1965, Laszlo told Klara, his future bride, how his kids’ education would go. He had studied the lives of geniuses and divined a pattern: an adult singularly focused on the child’s success. He’d raise the kids outside school, with intense devotion to a subject, though he wasn’t sure what. "Every healthy child," as he liked to say, "is a potential genius." Genetics and talent would be no obstacle. And he’d do it with great love. ... Computers have long since outclassed humans in chess; they’re vital in training, but their recommended moves can seem quixotic. "No, it’s very human," Polgár assured them. The students, most of them grandmasters, grew quiet, searching the more than 100,000 positional situations they had ingrained over their lifetimes, exploring possible moves and the future problems they implied — moving down the decision tree. It’s the knot at the heart of chess: Each turn, you must move; when you move, a world of potential vanishes. ... "It’s important to look at top performers to look at the limits of human abilities — the maximum adaptations people can undergo." By looking to the best, we can understand the rest.

The race is on to breed better birds as chicken emerges as the protein of the masses ... Unlike the roughly 60 billion chickens world-wide now slaughtered for meat each year, these birds are raised for their DNA. Paul Siegel, professor emeritus of animal and poultry sciences, studies how their genes influence the way they pack on pounds and fight off disease. The research helps companies seeking to breed chickens that will grow faster on less feed and require fewer drugs to stay healthy. ... Food producers face a monumental task. At current consumption rates, the world would need to generate 455 million metric tons of meat annually by 2050, when the global population is expected to reach 9.7 billion, from 7.3 billion today. Given today’s agricultural productivity, growing the crops to feed all of that poultry, beef and other livestock would require every acre of the planet’s cropland, according to research firm FarmEcon LLC—leaving no room for raising the grains, fruits and vegetables that humans also need. ... Chicken’s rise already is changing time-honored habits. In Argentina, where grass-fed beef has long been central to daily life, per-capita poultry consumption is projected to climb 7.5% this year to a record level, while beef consumption is expected to decline 6.3%. Even in pork-loving China, the government has subsidized large-scale poultry farms and breeding operations over the past decade to increase output.

Paleogenetics is helping to solve the great mystery of prehistory: how did humans spread out over the earth? ... Before the Second World War, prehistory was seen as a series of invasions, with proto-Celts and Indo-Aryans swooping down on unsuspecting swaths of Europe and Asia like so many Vikings, while megalith builders wandered between continents in indecisive meanders. After the Second World War, this view was replaced by the processual school, which attributed cultural changes to internal adaptations. Ideas and technologies might travel, but people by and large stayed put. Today, however, migration is making a comeback. ... Much of this shift has to do with the introduction of powerful new techniques for studying ancient DNA. ... Whole-genome sequencing yields orders of magnitude more data than organelle-based testing, and allows geneticists to make detailed comparisons between individuals and populations. Those comparisons are now illuminating new branches of the human family tree. ... In five years, we’ve gone from thinking we shared no DNA with Neanderthals, to realising that there was widespread interbreeding, to pinpointing it (for one individual) within 200 years – almost the span of a family album. But the use of ancient DNA isn’t limited to our near-human relatives. It is also telling us about the dispersal of humans out of Africa, and the origin and spread of agriculture, and the peopling of the Americas. It is also helping archaeologists crack one of the great mysteries of prehistory: the origins of the Indo-Europeans.

Calories consumed minus calories burned: it’s the simple formula for weight loss or gain. But dieters often find that it doesn’t work. ... more than two-thirds of American adults are overweight or obese. For many of them, the cure is diet: one in three are attempting to lose weight in this way at any given moment. Yet there is ample evidence that diets rarely lead to sustained weight loss. These are expensive failures. This inability to curb the extraordinary prevalence of obesity costs the United States more than $147 billion in healthcare, as well as $4.3 billion in job absenteeism and yet more in lost productivity. ... part of the problem goes way beyond individual self-control. The numbers logged in Nash’s Fitbit, or printed on the food labels that Haelle reads religiously, are at best good guesses. Worse yet, as scientists are increasingly finding, some of those calorie counts are flat-out wrong – off by more than enough, for instance, to wipe out the calories Haelle burns by running an extra mile on a treadmill. A calorie isn’t just a calorie. And our mistaken faith in the power of this seemingly simple measurement may be hindering the fight against obesity.

His latest venture, Human Longevity, Inc., or HLI, creates a realistic avatar of each of its customers – they call the first batch ‘voyagers’ – to provide an intimate, friendly interface for them to navigate the terabytes of medical information being gleaned about their genes, bodies and abilities. Venter wants HLI to create the world’s most important database for interpreting the genetic code, so he can make healthcare more proactive, preventative and predictive. Such data marks the start of a decisive shift in medicine, from treatment to prevention. Venter believes we have entered the digital age of biology. And he is the first to embark on this ultimate journey of self-discovery. ... His critics call him arrogant but, having talked to him on and off for more than two decades, I think Venter has earned the right to be bullish about his abilities to build a biotech venture from scratch. ... So far, HLI has amassed the sequences of around 20,000 whole genomes, says Venter (he won’t be drawn on whether it is the biggest cache – probably, but he adds that it depends on the details and that “all kinds of people make all kinds of claims”). But, of course, he wants even more. The company has room for more sequencing facilities on its third floor and is considering a second centre in Singapore, planning to rapidly scale to sequencing the genomes of 100,000 people per year – whether children, adults or centenarians, and including both those with disease and those who are healthy. By 2020, Venter aims to have sequenced a million genomes. ... in about a month, each Illumina sequencer can tear through 16 human genomes at the same coverage in just three days. Each week, these machines pump terabytes of data into the cloud run by Amazon Web Services. ... Venter says their findings have changed his static view of the genome. For instance, he has been able to compare his 2006 genome with today’s, using three different sequencing technologies. “One of the findings that would have shocked me and the rest of the world 15 years ago is that our genome is continually changing,” he says. “We can relatively accurately predict your age from your genome sequence, or at least the age when the sample was taken.” ... Targeted initially at self-insured executives and athletes, a full health scan will be priced at $25,000.

Patrick Soon-Shiong wants to turn cancer treatment upside down. On January 12, Soon-Shiong and a consortium of industry, government, and academia announced the launch of the Cancer MoonShot 2020, an ambitious program aiming to replace a long history of blunt trial-and-error treatment with what amounts to a training regimen for the body’s own immune system. That system, Soon-Shiong argues, is perfectly adept at finding and eliminating cancer with exquisite precision—if it can recognize the mutated cells in the first place. Helping it to do so could represent a powerful new treatment for the disease, akin to a flu vaccine. ... Soon-Shiong has hit home runs before. This past July, one of his firms underwent the highest-value biotech IPO in history. A cancer drug he developed, called Abraxane, is approved to fight breast, lung, and pancreatic cancers in more than 40 countries. Soon-Shiong’s path from medical school in South Africa through residency in Canada, to UCLA professor, NASA researcher and corporate CEO has given him the bird’s-eye view necessary to take on a project this ambitious, as well as the resources to marshal the world-class computing and genome-sequencing facilities that it requires.

Samumed is finding it easy to raise huge amounts of cash because it believes it has invented medicines that can reverse aging. Its first drugs are targeted at specific organ systems. One aims to regrow hair in bald men. The same drug may also turn gray hair back to its original color, and a cosmetic version could erase wrinkles. A second drug seeks to regenerate cartilage in arthritic knees. Additional medicines in early human studies aim to repair degenerated discs in the spine, remove scarring in the lungs and treat cancer. After that Samumed will attempt to cure a leading cause of blindness and go after Alzheimer’s. The firm’s focus, disease by disease, symptom by symptom, is to make the cells of aging people regenerate as powerfully as those of a developing fetus. ... Hood, 49, had invented a cancer drug that got his previous company, Targegen, bought by Sanofi for $635 million. He has a distinct take on drug development: He thinks everybody takes too many shortcuts and insists on doing work himself that other companies outsource, including formulating drug chemistry, testing drugs in laboratory animals and running clinical trials. ... The target Hood and Kibar went after was obvious: a gene called Wnt, which stands for “wingless integration site,” because when you knock it out in fruit flies, they never grow wings. It’s a linchpin in a group of genes that control the growth of a developing fetus–whether you’re a fly or a person. Together these genes are known as the Wnt pathway. Trigger the right ones and you might revive old flesh. Some cancers do their dirty work by hijacking Wnt, and blocking it might stop tumors.

Yannis Pitsiladis, scientist and provocateur, had come here for the same reason that pilgrims wheezing with bronchitis and emphysema have headed to this low-altitude divide between Israel and Jordan. He had come for the oxygen. ... A quarter-mile below sea level at the Dead Sea, where the barometric pressure is high, there is about 5 percent more oxygen to breathe. The naturally enriched air had been shown to increase exercise capacity in those with chronic lung disease. Would it do the same, Pitsiladis wondered, for the world’s fastest distance runners? ... He wanted to redefine the limits of human endurance by training a man to run a marathon in less than two hours without the use of performance-enhancing drugs. ... The Sub2 Project, as it is called, is an attempt at the extraordinary — to reduce by nearly three minutes the world record of 2 hours 2 minutes 57 seconds, set at the 2014 Berlin Marathon by Dennis Kimetto of Kenya. ... Some consider the goal impossible. Many are suspicious because of widespread doping in track and field, and almost no one considers the feat achievable anytime soon. ... To run under two hours without the use of banned drugs would be to set a record that would stand with the four-minute mile as an ultimate test of human stamina. ... A 1:59:59 marathon would require a searing pace of 4 minutes 34 seconds per mile, seven seconds faster than the pace of the current world record. It would require 85 to 90 percent of a runner’s maximum aerobic capacity — twice the capacity of an average man — and a sustained heart rate of about 160 to 170 beats per minute.

It seemed absolutely crazy. The idea that an Iowa housewife, equipped with the cutting-edge medical tool known as Google Images, would make a medical discovery about a pro athlete who sees doctors and athletic trainers as part of her job? ... First, it was with her family’s Emery-Dreifuss, then when she thought they had lipodystrophy, and now she thought that she and Priscilla just must have a mutant gene in common because of the exact same pattern of missing fat. But how, then, did Priscilla get a double-helping of muscle while Jill’s muscles were scarcely there?

It starts with a single gene, out of some 20 to 25,000, coding for the more than 30 trillion cells in a human body. Take the length of the DNA in those cells, unravel it, and you have a distance of more than 400 lengths from the sun to the Earth. The human genome has 6 billion data points of information. Six billion ways for something to go incredibly right — or incredibly wrong. ... Sorting through these possibilities is the job of Stanford University scientist Euan Ashley. The 45-year-old Scotsman is a cardiologist, a systems biologist, and one of the leaders of a new, integrated approach to the science of genetics. He led the first team to clinically interpret a full human genome; he’s involved in attempts to sequence cancer genomes for personalized treatment and to analyze the genomes of individuals who have rare and unknown diseases. But for the last several years, his work has focused on a specific mystery. He is looking for superhero genes ... “We’re interested in truly the fittest people on the planet,” he explained. Though there are many factors that may make someone elite, his team made the decision to select athletes on the basis of a single, objective physiological variable: the maximum amount of oxygen a body can use, or VO2max. VO2max is considered one of the most important markers not only for athletic success, but for overall health: It’s such a crucial indicator of cardiovascular function that it is used to determine whether someone requires a heart transplant. VO2max has also been measured in the same way for half a century, which means it can be a useful comparative point. ... To be a part of the study, men need to test at a VO2max that exceeds 75 milliliters of oxygen per minute; for women, the cutoff is 63. Fewer than .00172 percent of the population qualify.

Oxitec is trying to leverage this mating instinct to help wipe out one particular species of mosquito: Aedes aegypti, carrier and spreader of some of the worst insect-borne diseases known to medicine—dengue, malaria, and Zika. The A. aegypti mosquito has evolved to survive even the most effective pesticides. It can lay 500 eggs in just a bottle cap’s worth of water, and it prefers to bite humans over animals, so it lives in places where no one thinks to spray, like under the couch. ... The idea behind Oxitec’s experiment is that if enough genetically modified male A. aegypti mosquitoes are released into the wild, they’ll track down large numbers of females in those hard-to-find places and mate with them. The eggs that result from any union with an Oxitec mosquito will carry a fatal genetic trait engineered into the father—a “kill switch,” geneticists call it. The next generation of A. aegypti mosquitoes will never survive past the larval stage, never fly, never bite, and never spread disease. No mosquitoes, no Zika. ... Oxitec is far from the first company or research team that’s tried to sterilize an entire insect population. Scientists have been going after A. aegypti in this way since the 1970s, usually by irradiating them. The problem with radiation is that it makes the mosquitoes too weak to get out and breed. The great innovation of the Oxitec method is that it cleverly achieves the same result as sterilization, while leaving mosquitoes able to do what mosquitoes do. ... Oxitec charges about $7.50 per person per year in each area it treats.

If you were able to observe this creature in person, which is hard to do, given that they live in only a few places on earth, you would find it in a family network—a harem—with a dominant stallion watching over mares and their offspring, in groups of 5 to 15. For this to happen, you would have to be in Mongolia, Kazakhstan, China or Russia, the only places the horse lives anymore in the wild. ...  You don’t ride the takhi, or stable it, or—pony-like as the horse appears—saddle it up and perch children on it at birthday parties. The horse is too wild for that. While it has been captured and occasionally confined to zoos, it has never been tamed—it is the only truly wild horse in existence. Other horses that are thought of as wild are in fact feral. ... There are roughly 2,000 takhi in the world right now, and the largest number of them live at Hustai National Park, within 60 miles of Mongolia’s capital, Ulaanbaatar.

The company’s mission: to build a Bell Labs of aging research. It hoped to extend the human life span by coming up with a breakthrough as important, and as useful to humanity, as the transistor has been. ... Google’s founders created an academic-biotech hybrid they call an R&D company to follow up on such clues, providing nearly unlimited funding to a group of top researchers. ... despite the hype around its launch—Time magazine asked, “Can Google Solve Death?”—Calico has remained a riddle, a super-secretive company that three years in hasn’t published anything of note, rebuffs journalists, and asks visiting scientists to sign nondisclosure agreements. ... Right now, there’s no proven test for a person’s “biological” age; finding one would be scientifically useful and possibly lucrative. ... For all these diseases, aging is the single biggest risk factor. An 80-year-old is 40 times as likely to die from cancer as someone middle-aged. The risk for Alzheimer’s rises by 600 times. But what if it were possible to postpone all these deaths by treating aging itself? … The experiment will generate millions of readings—for levels of growth hormones and glucose, among other things. Churchill wouldn’t say how much Calico is paying, but simply feeding that many mice could cost $3 million.

Reversing Paralysis: Scientists are making remarkable progress at using brain implants to restore the freedom of movement that spinal cord injuries take away.
Self-Driving Trucks: Tractor-trailers without a human at the wheel will soon barrel onto highways near you. What will this mean for the nation’s 1.7 million truck drivers?
Paying with Your Face: Face-detecting systems in China now authorize payments, provide access to facilities, and track down criminals. Will other countries follow?
Practical Quantum Computers: Advances at Google, Intel, and several research groups indicate that computers with previously unimaginable power are finally within reach.
The 360-Degree Selfie: Inexpensive cameras that make spherical images are opening a new era in photography and changing the way people share stories.
Hot Solar Cells: By converting heat to focused beams of light, a new solar device could create cheap and continuous power.
Gene Therapy 2.0: Scientists have solved fundamental problems that were holding back cures for rare hereditary disorders. Next we’ll see if the same approach can take on cancer, heart disease, and other common illnesses.
The Cell Atlas: Biology’s next mega-project will find out what we’re really made of.
Botnets of Things: The relentless push to add connectivity to home gadgets is creating dangerous side effects that figure to get even worse.
Reinforcement Learning: By experimenting, computers are figuring out how to do things that no programmer could teach them.

For decades, the solution to aging has seemed merely decades away. In the early nineties, research on C. elegans, a tiny nematode worm that resembles a fleck of lint, showed that a single gene mutation extended its life, and that another mutation blocked that extension. The idea that age could be manipulated by twiddling a few control knobs ignited a research boom, and soon various clinical indignities had increased the worm’s life span by a factor of ten and those of lab mice by a factor of two. The scientific consensus transformed. Age went from being a final stage (a Time cover from 1958: “Growing Old Usefully”) and a social issue (Time, 1970: “Growing Old in America: The Unwanted Generation”) to something avoidable (1996: “Forever Young”) or at least vastly deferrable (2015: “This Baby Could Live to Be 142 Years Old”). Death would no longer be a metaphysical problem, merely a technical one. ... The celebration was premature. Gordon Lithgow, a leading C. elegans researcher, told me, “At the beginning, we thought it would be simple—a clock!—but we’ve now found about five hundred and fifty genes in the worm that modulate life span. And I suspect that half of the twenty thousand genes in the worm’s genome are somehow involved.” That’s for a worm with only nine hundred and fifty-nine cells. ... For us, aging is the creeping and then catastrophic dysfunction of everything, all at once. ... The great majority of longevity scientists are healthspanners, not immortalists. They want to give us a healthier life followed by “compressed morbidity”—a quick and painless death. ... The battle between healthspanners and immortalists is essentially a contest between the power of evolution as ordained by nature and the potential power of evolution as directed by man. ... Aging doesn’t seem to be a program so much as a set of rules about how we fail. Yet the conviction that it must be a program is hard to dislodge from Silicon Valley’s algorithmic minds. If it is, then reversing aging would be a mere matter of locating and troubleshooting a recursive loop of code.

The men and women who are trying to bring down cancer are starting to join forces rather than work alone. Together, they are winning a few of the battles against the world's fiercest disease. ... It's not like you don't have cancer and then one day you just do. Cancer—or, really, cancers, because cancer is not a single disease—happens when glitches in genes cause cells to grow out of control until they overtake the body, like a kudzu plant. Genes develop glitches all the time: There are roughly twenty thousand genes in the human body, any of which can get misspelled or chopped up. Bits can be inserted or deleted. Whole copies of genes can appear and disappear, or combine to form mutants. ... Cancer is not an ordinary disease. Cancer is the disease—a phenomenon that contains the whole of genetics and biology and human life in a single cell. It will take an army of researchers to defeat it.

As space exploration geared up in the 1960s, scientists were faced with a new dilemma. How could they recognize life on other planets, where it may have evolved very differently—and therefore have a different chemical signature—than it has on Earth? James Lovelock, father of the Gaia theory, gave this advice: Look for order. Every organism is a brief upwelling of structure from chaos, a self-assembled wonder that must jealously defend its order until the day it dies. Sophisticated information processing is necessary to preserve and pass down the rules for maintaining this order, yet life is built out of the messiest materials: tumbling chemicals, soft cells, and tangled polymers. Shouldn’t, therefore, information in biological systems be handled messily, and wasted? In fact, many biological computations are so perfect that they bump up against the mathematical limits of efficiency; genius is our inheritance.

Suppose you wanted to build the perfect dog from scratch. What would be the key ingredients in the recipe? Loyalty and smarts would be musts. Cuteness would be as well, perhaps with gentle eyes, and a curly, bushy tail that wags in joy in anticipation of your appearance. ... You needn’t bother trying. Lyudmila Trut and Dmitri Belyaev have already built it for you. The perfect dog. Except it’s not a dog, it’s a fox. A domesticated one. They built it quickly—mind-bogglingly fast for constructing a brand new biological creature. It took them less than 60 years, a blink of an eye compared to the time it took for wolves to become dogs. They built it in the often unbearable negative 40 degrees Fahrenheit cold of Siberia, where Lyudmila and, before her, Dmitri, have been running one of the longest, most incredible experiments on behavior and evolution ever devised. ... Except for house pets, most domesticated animals do not form close relationships with humans, and by far the most intense affection and loyalty forms between owners and dogs. What made the difference? Had that deep human-animal bond developed over a long time? Or might this affinity for people be a change that could emerge quickly, as with so many other changes Lyudmila and Belyaev had seen in the foxes already? Would living with a human come naturally to a fox that had been bred for tameness?