February 11, 2016
His latest venture, Human Longevity, Inc., or HLI, creates a realistic avatar of each of its customers – they call the first batch ‘voyagers’ – to provide an intimate, friendly interface for them to navigate the terabytes of medical information being gleaned about their genes, bodies and abilities. Venter wants HLI to create the world’s most important database for interpreting the genetic code, so he can make healthcare more proactive, preventative and predictive. Such data marks the start of a decisive shift in medicine, from treatment to prevention. Venter believes we have entered the digital age of biology. And he is the first to embark on this ultimate journey of self-discovery. ... His critics call him arrogant but, having talked to him on and off for more than two decades, I think Venter has earned the right to be bullish about his abilities to build a biotech venture from scratch. ... So far, HLI has amassed the sequences of around 20,000 whole genomes, says Venter (he won’t be drawn on whether it is the biggest cache – probably, but he adds that it depends on the details and that “all kinds of people make all kinds of claims”). But, of course, he wants even more. The company has room for more sequencing facilities on its third floor and is considering a second centre in Singapore, planning to rapidly scale to sequencing the genomes of 100,000 people per year – whether children, adults or centenarians, and including both those with disease and those who are healthy. By 2020, Venter aims to have sequenced a million genomes. ... in about a month, each Illumina sequencer can tear through 16 human genomes at the same coverage in just three days. Each week, these machines pump terabytes of data into the cloud run by Amazon Web Services. ... Venter says their findings have changed his static view of the genome. For instance, he has been able to compare his 2006 genome with today’s, using three different sequencing technologies. “One of the findings that would have shocked me and the rest of the world 15 years ago is that our genome is continually changing,” he says. “We can relatively accurately predict your age from your genome sequence, or at least the age when the sample was taken.” ... Targeted initially at self-insured executives and athletes, a full health scan will be priced at $25,000.
Judging from its modern incarnation in fiction, a new kind of apocalypse is upon us, one that is both more compelling and more terrifying. Today our fears are broader, deeper, woven more tightly into our daily lives, which makes it feel like the seeds of our destruction are all around us. We are more afraid, but less able to point to a single source for our fear. At the root is the realisation that we are part of something beyond our control. ... In the annals of eschatology, we are living in a golden age. The end of the world is on everyone’s mind. Why now? In the recent past we were arguably much closer to the end – just a few nuclear buttons had to be pushed. ... Humans have always been an organised species. We have always functioned as a group, as something larger than ourselves. But in the recent past, the scale of that organisation has grown so much, the pace of that growth is so fast, the connective tissue between us so dense, that there has been a shift of some kind. Namely, we have become so powerful that some scientists argue we have entered a new era, the Anthropocene, in which humans are a geological force. ... My life depends on technologies I don’t understand, signals I can’t see, systems I can’t perceive. I don’t understand how any of it works, how I could change it, or how it can last. Its feels like peering across some chasm, like I am part of something I cannot quite grasp, like there has been a phase shift from humans struggling to survive to humanity struggling to survive our success.
More so than the average American sitcom, Seinfeld has had difficulty reaching global audiences. While it’s popular in Latin America, it hasn’t been widely accepted in Germany, France, Italy, and the Netherlands. Two decades after it went off the air, Seinfeld remains relevant to American audiences — thanks in part to omnipresent syndicated reruns — but in much of Europe it is considered a cult hit, and commonly relegated to deep-late-night time slots. Its humor, it seems, is just too complicated, too cultural and word-based, to make for easy translation. ... Jokes are the hardest things to translate into another language, another culture, another world. A good script for dubbing an American sitcom for foreign consumption does more than literally translate. It manages to convey the same meaning, the same feeling, the same story — the same direct hit to the lower frontal lobes of the brain that produces a laugh, even though those frontal lobes are steeped in a completely different cultural brew. ... Lip-synch dubbing, despite its ultimate benefits, can get very complicated. It’s not just that the lines may not translate directly — they also have to take just as long to say in both languages and approximate, to the best of their abilities, the lip movements of the original actors. That can pose an added challenge when translating from laconic languages like English into verbose languages like German.
The verb to use in polite company is “cover.” The stud covers the mare. Or: About 11 months after she was covered, the mare gave birth to a healthy foal. ... The deed itself, here in the hills of Kentucky horse country, is governed by strict rules. Section V, paragraph D of The American Stud Book Principal Rules and Requirements is clear: “Any foal resulting from or produced by the processes of Artificial Insemination, Embryo Transfer or Transplant, Cloning or any other form of genetic manipulation not herein specified, shall not be eligible for registration.” No shortcuts, no gimmicks. All thoroughbreds must be the product of live, all-natural, horse-on-horse action. ... two weeks after American Pharoah retired, his 2016 stud fee was set at $200,000, the highest ever for an unproven, first-year stallion. Only one other active stud—a tested, 15-year-old veteran named Tapit—commands that much per successful cover. Tapit’s first-year fee was $15,000; his rate rose to its current $300,000 only after a decade of producing stakes-winning foals. ... Successful stallions are routinely matched with more than 100 mares in a five-month breeding season. Particularly energetic ones might cover as many as 200 a year. If American Pharoah produces several seasons of healthy and fast foals, standard pricing norms suggest that his stud fee will multiply exponentially. Very quickly, the $8.6 million he earned during his racing career would begin to look like small change.